该季本应在2020年9月首映，但由于新冠病毒因素，世界范围的旅行限制，斐济对非公民关闭了边境，最终推迟在2021年春季，制作被搁置了整整一年。本季于2021年9月22日在美国哥伦比亚广播公司（CBS）和加拿大环球电视台（Global）首映。与往季不同，通常39天的赛制被缩短到26天。

　　本季紧随第41季连续制作拍摄，同样在斐济岛取景，同样因为疫情将39天的赛程缩短至26天。选手因为没有看过第41季的相关内容，因此第41季出现的变数像“疯狂密语”等将继续保留，同时又增加了新的变数，这将是又一次新的进化。

　　Stranded in the beautiful islands of Fiji, 18 determined new castaways will be divided into 3 tribes of 6 and forced to form a new society as they adapt to their physical and social surroundings.

　　LEGO Friends' First Movie Ever! The girls' friendships are tested when mega-popstar Livi comes to Heartlake City. When our friends' hit song "Girlz" is stolen by Livi's manager, it's time for a cunning plan. As the girls try to tell Livi the truth about her latest hit single, they all learn that fame isn't everything and sometimes friendship is the most precious thing in the world. Join Olivia, Stephanie, Emma, Mia and Andrea as they learn one of life's most important lessons while having fun along the way.

　　吴大福与老虎仔兄弟情深，老虎仔因意外入院，昏迷不醒。大福即往泰国向灵神祈求，甘愿以自己所有折半换回老虎仔一命。老虎仔果然康复。兄弟分别追求两位漂亮女护士。但大福发觉自己的东西开始减半，急忙找术士卜问避祸……

　　一个普通快递青年孤儿，阴差阳错被认作失落民间的首富之子，360度的转变，让他的生活和人际立马改变，但最后真相大白，快递小哥尝过人间冷暖，并获得爱情，亲情。

　　Ricky, a top contender in Muay Thai Kickboxing trains for the title belt, all the while dealing with new relationships, money problems, and family drama.

　　讲述女高中生为实现梦想而打破女性不能成为职业棒球运动员的惯例，成为韩国首位女性职业棒球运动员的故事，郭东延在影片中饰演自幼与女主人公一起长大，早早就成为职业棒球选手，与女主人公既是朋友，又是竞争对手的角色。

　　A screen adaptation of the hit play about the exploits of a group of Liverpool Football fans at the European Cup final in Istanbul.

　　A masked killer begins murdering students on the school track team after a track runner dies upon completion of a 30 second 200-meter race.

　　A murderous shapeshifter sets out on a blood-soaked mission to make things right with the woman he loves.

　　《行运舞狮队》用一支业余舞狮队的奋斗，展现岭南农村的传统与现代之辩。